Quebec Database of clinical data and biological material for research on uveal melanoma
Funded since 2013
Goal
Sharing biological material and clinical data from patients with uveal melanoma.
Description
Uveal melanoma is the most common intraocular malignancy in the adult population. Since familial cases of this cancer are very rare, it is difficult to prevent or detect it. Despite effective treatment of eye tumours, over 50% of patients develop incurable metastases, mainly to the liver, within 15 years of diagnosis of the primary tumour. Around 20 samples are taken in Quebec each year, and the biopsies obtained for research purposes are small. This provincial infrastructure pools biological material from donors suffering from uveal melanoma, combined with a clinical database. Biopsies taken from tumors or metastases are used to culture cell lines and carry out genetic/proteomic/biomechanical studies.
Impact
This infrastructure plays an important role in the achievement of various research programs for a better understanding of genetic and environmental factors involved in the development of melanoma and the spread of metastasis. It allows collaboration with other researchers at a provincial, national and international level in order to make progress in basic and clinical research on uveal melanoma.
Accessibility
The biological material and clinical data of this infrastructure are available upon request to VHRN members whose research project was approved by the ethics committee of the institution.
Infrastructure administrator
Solange Landreville, PhD, Département d’ophtalmologie et oto-rhino-laryngologie – chirurgie cervico-faciale, Université Laval
Contact information
Solange Landreville – Solange.Landreville@fmed.ulaval.ca
Funding
Réseau de recherche en santé de la vision, Fonds de recherche du Centre universitaire d’ophtalmologie du CHU de Québec (infirmière de recherche)
