Réseau de recherche en santé de la vision Logo fonds de la recherche du Québec - santé Logo

Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., Diaz-Marin, R., Parinot, C., Guber, V., Pilon, F., Juneau, R., Laflamme, R., Sawchyn, C., Boulay, K., Leclerc, S., Abu-Thuraia, A., Côté, J.-F., Andelfinger, G., Rezende, F. A., Sennlaub, F., Joyal, J.-S., Mallette, F. A., Sapieha, P. (2020) "Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy" Science, Vol. 369.

Download the article


In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we used orthogonal approaches in human patients with proliferative diabetic retinopathy and a mouse model of ischemic retinopathies to identify an unconventional role for neutrophils in vascular remodeling during late-stage sterile inflammation. Senescent vasculature released a secretome that attracted neutrophils and triggered the production of neutrophil extracellular traps (NETs). NETs ultimately cleared diseased endothelial cells and remodeled unhealthy vessels. Genetic or pharmacological inhibition of NETosis prevented the regression of senescent vessels and prolonged disease. Thus, clearance of senescent retinal blood vessels leads to reparative vascular remodeling.

Figures combinées

Salle de presse


News on Centre de recherche de l’Hôpital-Maisonneuve-Rosemont

News on udm news « Promising discovery for patients with diabetic retinopathy »

News on Centre de recherche de l’Hôpital-Sainte-Justine « Promising discovery for patients with diabetic retinopathy »

News on Medical Press