Vision Health Research Network

Recent publications of the Retina and Posterior Segment axis

Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi A, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, …Sapieha P (2024). "Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results" Nature Medicine. Feb

Alarcon-Martinez, L., Shiga, Y., Villafranca-Baughman, D., Belforte, N., Quintero, H., Dotigny, F., Cueva Varga, J. L., Di Polo, A. (2022). "Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma" PNAS, Vol. 119.

Javed A., Mattar, P., Lu, S., Kruczek, K., Kloc, M., Gonzalez-Cordero, A., Bremner, R., Ali, R. R., Cayouette, M. (2020) "Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina" Development, Vol. 147.

Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., Diaz-Marin, R., Parinot, C., Guber, V., Pilon, F., Juneau, R., Laflamme, R., Sawchyn, C., Boulay, K., Leclerc, S., Abu-Thuraia, A., Côté, J.-F., Andelfinger, G., Rezende, F. A., Sennlaub, F., Joyal, J.-S., Mallette, F. A., Sapieha, P. (2020) "Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy" Science, Vol. 369.

Alarcon-Martinez, L.,Villafranca-Baughman, D., Quintero, H., Kacerovsky, J. B., Dotigny, F., Murai, K. K., Prat, A., Drapeau, P.,Di Polo, A. (2020) "Interpericyte tunnelling nanotubes regulate neurovascular coupling" Nature 585(7823):91-95

Chiu CW, Monat C, Robitaille M, Lacomme M, Daulat AM, Macleod G, McNeill H, Cayouette M, Angers S. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev Cell. 2016

A conserved regulatory logic controls temporal identity in mouse neural progenitors. Mattar P, Ericson J, Blackshaw S, Cayouette M. Neuron. 2015 Feb 4;85(3):497-504.

Dejda A, Mawambo G, Cerani A, Miloudi K, Shao Z, Daudelin JF, Boulet S, Oubaha M, Beaudoin F, Akla N, Henriques S, Menard C, Stahl A, Delisle JS, Rezende FA, Labrecque N, Sapieha P. Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. J Clin Invest. 2014 Nov 3;124(11):4807-22.

Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, Hardy P, Bhosle V, Varma DR, Gobeil F Jr, Beauséjour C, Boileau C, Klein W, Hollenberg M, Ribeiro-da-Silva A, Andelfinger G, Chemtob S. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med. 2014 Oct;20(10):1165-73.

Mathieu Gauvin, Jean-Marc Lina, and Pierre Lachapelle. Advance in ERG Analysis: From Peak Time and Amplitude to Frequency, Power, and Energy. Biomed Res Int. 2014;2014:246096

Agustin Cerani, Nicolas Tetreault, Catherine Menard, Eric Lapalme, Chintan Patel, Nicholas Sitaras, Felix Beaudoin, Dominique Leboeuf, Vincent De Guire, François Binet, Agnieszka Dejda, Flavio A. Rezende, Khalil Miloudi, Przemyslaw Sapieha. Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab. 2013 Oct 1;18(4):505-18.

Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Nageeb M; Finding of Rare Disease Genes (FORGE) Canada Consortium, Poulter JA, Mohamed MD, Jafri H, Rashid Y, Taylor GR, Keser V, Mardon G, Xu H, Inglehearn CF, Fu Q, Toomes C, Chen R. Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet. sept 2012, 44(9):1035-9.

Dorfman AL, Cuenca N, Pinilla I, Chemtob S, Lachapelle P. Immunohistochemical evidence of synaptic retraction, cytoarchitectural remodeling, and cell death in the inner retina of the rat model of oygen-induced retinopathy (OIR). Invest Ophthalmol Vis Sci. 2011, 52(3):1693-708.

Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood. 2011 Jun 2;117(22):6024-35.

Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, Guimond M, Kennedy TE, Sapieha P. Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell Metab. 2013 Mar 5;17(3):353-71.

Landreville S, Vigneault F, Bergeron MA, Leclerc S, Gaudreault M, Morcos M, Mouriaux F, Salesse C, Guérin SL. Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines. Pigment Cell Melanoma Res. 2011 Aug;24(4):643-55.